J Oral Maxillofac Surg. 2025 May 21:S0278-2391(25)00291-5. doi: 10.1016/j.joms.2025.05.008. Online ahead of print.
ABSTRACT
BACKGROUND: Virtual surgical planning (VSP) for composite microvascular free flaps has become the standard-of-care for oncologic head and neck reconstruction. Controversy remains on the routine use of three-dimensional-printed titanium patient-specific implants (PSIs) or traditional hand-contoured stock reconstruction plates.
PURPOSE: The purpose of this study was to compare hardware-related complications of PSIs versus stock reconstruction plates among subjects undergoing VSP-guided fibular free flap reconstructions.
STUDY DESIGN/SETTING/SAMPLE: A retrospective cohort study of subjects undergoing VSP-guided fibular free flaps at Mayo Clinic between 2014 and 2023 was undertaken. Exclusion criteria included subjects not undergoing a VSP-guided surgery, bony microvascular reconstruction other than a fibular free flap, less than 1 year of postoperative follow-up, and inadequate documentation of requisite clinical variables in the electronic medical record.
PREDICTOR VARIABLE: The primary predictor variable was the type of reconstruction plate utilized (PSI vs stock plate).
MAIN OUTCOME VARIABLE: The main outcome variable was potential hardware-related complications defined as: hardware fracture, hardware loosening, postoperative infection, hardware extrusion, hardware removal, nonunion bone healing, and osteoradionecrosis.
COVARIATES: Covariates included subject age, sex, and preoperative diagnosis.
ANALYSIS: Associations of complication-free survival with plate type were analyzed with Kaplan-Meier survival curves. Formal associations were calculated using Cox proportional hazards regression analysis, modeling time to complication as the outcome and plate type as the exposure.
RESULTS: A total of 265 subjects were identified, 183 (69%) receiving PSIs, and 82 (31%) receiving stock plates. Seventy-two subjects (27%) experienced at least 1 postoperative hardware-related complication. Multivariate Cox proportional hazards regression demonstrated that stock plates were nearly twice as likely to experience at least 1 hardware-related complication compared to PSIs (hazard ratio: 1.80, 95% CI: 1.11 to 2.91, P = .0171).
CONCLUSION AND RELEVANCE: Use of PSIs in the modern era of VSP-guided fibular free flap reconstruction is associated with a nearly 2-fold reduction in postoperative hardware-related complications over stock reconstruction plates.
PMID:40480278 | DOI:10.1016/j.joms.2025.05.008