J Orthop Surg (Hong Kong). 2025 Sep-Dec;33(3):10225536251408918. doi: 10.1177/10225536251408918. Epub 2025 Dec 19.ABSTRACTPurposeThis study investigates the efficacy of antibiotic-loaded bone cement followed by autogenous iliac bone grafting in managing subacute/chronic phalangeal osteomyelitis (OM)
Stem Cell Rev Rep. 2025 Dec 20. doi: 10.1007/s12015-025-11040-1. Online ahead of print.ABSTRACTMesenchymal stromal cells (MSCs) have gained significant attention in regenerative medicine for their potential in treating a variety of diseases even intractable ones, due to their ability to differentiat
Sci Rep. 2025 Dec 19. doi: 10.1038/s41598-025-30870-0. Online ahead of print.ABSTRACTAccurate forecasting of disease progression is vital in glaucoma management. Ordinary least square regression (OLSR) analyses are not appropriate to perform trend analysis on longitudinally collected perimetry data.
BMJ Glob Health. 2025 Dec 19;10(12):e018265. doi: 10.1136/bmjgh-2024-018265.ABSTRACTINTRODUCTION: More than 75% of the global population resides in low- and middle-income countries (LMICs), where healthcare-associated infection rates are notably higher than in high-income countries. Little is known
J Neural Eng. 2025 Dec 19. doi: 10.1088/1741-2552/ae2f9c. Online ahead of print.ABSTRACTThis review paper focuses on how both direct current (DC) stimulation and alternating current (AC) stimulation affects the central nervous system's (CNS) cells and its potential as a neurotherapeutic. Furthermore
Cancer Immunol Immunother. 2025 Dec 19;75(1):19. doi: 10.1007/s00262-025-04232-8.ABSTRACTIndoleamine 2,3-dioxygenase 1 (IDO1) facilitates tumor progression by catabolizing tryptophan into kynurenine (Kyn). While KHK2455, a selective IDO1 inhibitor, reduced Kyn levels in mouse tumors and plasma, it d
Cureus. 2025 Nov 17;17(11):e97104. doi: 10.7759/cureus.97104. eCollection 2025 Nov.ABSTRACTCommon hand pathologies that fail conservative management can be treated with corticosteroid injections. There are limited guidelines on the use of corticosteroids for hand and wrist pathologies. We aim to rev
Cureus. 2025 Nov 17;17(11):e97066. doi: 10.7759/cureus.97066. eCollection 2025 Nov.ABSTRACTInfection control plays a critical role in anesthesia. Anesthesia often involves close contact with patients and invasive procedures. Anesthesiologists care for patients before, during, and after surgery. This
Sichuan Da Xue Xue Bao Yi Xue Ban. 2025 Sep 20;56(5):1320-1325. doi: 10.12182/20250960506.ABSTRACTOBJECTIVE: To investigate the predictive value of changes in various indicators of routine blood tests for the severity of brain damage in patients with acute cerebral hemorrhage (ACH) in high-altitude
APL Bioeng. 2025 Dec 16;9(4):041505. doi: 10.1063/5.0282002. eCollection 2025 Dec.ABSTRACTLung cancer remains the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer accounting for a majority of cases. Despite advances in targeted therapies and immunotherapy, challen
Indian J Surg Oncol. 2025 Dec;16(6):1632-1638. doi: 10.1007/s13193-025-02276-x. Epub 2025 Mar 13.ABSTRACTBenign prostatic hyperplasia (BPH) and prostatic cancer both represent prostate lesions affecting males. These conditions occur due to the presence of inflammation within the prostate gland. This
Rev Bras Ginecol Obstet. 2025 Oct 21;47:e-rbgo85. doi: 10.61622/rbgo/2025rbgo85. eCollection 2025.ABSTRACTOBJECTIVE: To analyze the vaginal microbiota before and after the treatment with vaginal microablative fractional radiofrequency (FRAXX) and compare it with topical estriol treatment in women wi
bioRxiv [Preprint]. 2025 Dec 10:2025.12.06.692767. doi: 10.64898/2025.12.06.692767.ABSTRACTHIV-associated neurocognitive disorder (HAND) is characterized by glial activation and neuroinflammation emerging from HIV infection. Moreover, methamphetamine (METH) is a highly addictive psychostimulant whos
Ren Fail. 2025 Dec;47(1):2598982. doi: 10.1080/0886022X.2025.2598982. Epub 2025 Dec 18.ABSTRACTMaintenance hemodialysis (MHD) patients face high risks of malnutrition-inflammation complex syndrome, muscle atrophy, and cardio-cerebrovascular events (CCVE). These challenges have led to increasing atte
Hand (N Y). 2025 Dec 18:15589447251387356. doi: 10.1177/15589447251387356. Online ahead of print.ABSTRACTBACKGROUND: Currently, there is no consensus on the optimal surgical technique for scaphoid nonunion (arthroscopic vs open surgery). Open bone grafting is likely to result in better carpal alignm
Commun Med (Lond). 2025 Dec 18. doi: 10.1038/s43856-025-01301-y. Online ahead of print.ABSTRACTBACKGROUND: Secondary lymphedema is a common complication after breast cancer treatment. Traditional diagnostic techniques often lack objectivity, are prone to operator bias, and show limited reproducibili
Nat Commun. 2025 Dec 18. doi: 10.1038/s41467-025-67666-9. Online ahead of print.ABSTRACTCoxsackievirus A6 (CVA6), a major cause of hand, foot, and mouth disease, lacks approved vaccines or drugs. KRM1 is its only known receptor, but its precise role remains unclear. This study investigates CVA6's en
Br J Dermatol. 2025 Dec 19;193(Supplement_3):ljaf465.019. doi: 10.1093/bjd/ljaf465.019.ABSTRACTInfantile bullous pemphigoid (IBP) usually presents at 3-5 months of age and resolves rapidly with appropriate therapy. Unfortunately, diagnosis and effective treatment are often delayed as in the case rep
Laterality. 2025 Dec 18:1-17. doi: 10.1080/1357650X.2025.2599199. Online ahead of print.ABSTRACTNon-right-handed individuals appear to face greater risks for some psychiatric disorders than those right-handed. Whether an analogous association exists in the general child population and for whom (non-
Handchir Mikrochir Plast Chir. 2025 Dec 18. doi: 10.1055/a-2732-6576. Online ahead of print.ABSTRACTThere is strong evidence that carpal tunnel syndrome (CTS) - particularly when bilateral, recurrent or occurring in older adults - is frequently associated with a life-threatening systemic disease, tr
Expert Rev Gastroenterol Hepatol. 2025 Dec 19:1-5. doi: 10.1080/17474124.2025.2607008. Online ahead of print.ABSTRACTINTRODUCTION: Metabolic dysfunction-associated fatty liver disease (MAFLD) and metabolic dysfunction-associated steatotic liver disease (MASLD) represent an increasing global health c
PLoS One. 2025 Dec 18;20(12):e0338197. doi: 10.1371/journal.pone.0338197. eCollection 2025.ABSTRACTAsthma is a prevalent chronic disease worldwide, and individuals with asthma often experience reduced quality of life (QOL) due to symptoms such as dyspnea and impaired physical function. Given the vul
Altern Ther Health Med. 2025 Dec 16:AT11612. Online ahead of print.ABSTRACTBACKGROUND: The COVID-19 pandemic outbreak caused physical, psychological, and social problems all over the world, especially in individuals with chronic diseases such as diabetes mellitus. People have sought complementary an
Mol Biol Rep. 2025 Dec 18;53(1):206. doi: 10.1007/s11033-025-11367-5.ABSTRACTImmune checkpoints are a diverse group of cell-surface regulators which inhibit immune activation while maintaining self-tolerance. Inhibitory signaling and ligand competition enable molecules like PD-1, CTLA-4, LAG-3, TIM-
