J Safety Res. 2025 Jul;93:413-422. doi: 10.1016/j.jsr.2025.02.020. Epub 2025 Feb 25.
ABSTRACT
INTRODUCTION: The Carpal tunnel syndrome (CTS) is a frequent cause of hand symptoms and activity limitations, which is associated with various personal risk factors. However, the association between these risk factors and CTS under conditions of cumulative exposure to the risk factors remains unclear.
METHOD: In this study, we utilized a cumulative risk score to assess the prevalence level of CTS , and further evaluated the interactions between different risk factors and their cumulative association with CTS. Specifically, we first conducted a univariate regression analysis to evaluate the independent association of risk factors with CTS. Then we ran the multivariate regression model to filter out significant risk factors from risk factors associated with CTS. Next, we constructed the risk score to represent the cumulative association of significant risk factors with CTS, and we analyzed the relationship between the risk score and the prevalence level of CTS.
RESULTS: The experiment results demonstrated that among the various personal factors, sex, age, BMI, sleep disorder, smoking frequency, restlessness, diabetes, kidney failure, arthritis, and joint pain were the most significant factors related to CTS. There existed the cumulative association of risk factors with CTS, and the cumulative association of risk factors was positively related with an increased prevalence level of CTS. Moreover, there existed a critical threshold (risk score = 3) for the increase in the prevalence level of CTS.
CONCLUSIONS: Our study reveals the significant risk factors among personal factors related with CTS, and presents the cumulative association of these risk factors with CTS. Moreover, we offer the actionable suggestions for CTS prevention based on the experiment results.
PRACTICAL APPLICATIONS: The occurrence of CTS is associated with various risk factors. Identifying the independent and cumulative association of different risk factors is essential for designing effective preventive measures and interventions for CTS. Therefore, this study could be important for health management in CTS and other similar diseases.
PMID:40483078 | DOI:10.1016/j.jsr.2025.02.020