Front Cell Dev Biol. 2026 Feb 24;14:1776538. doi: 10.3389/fcell.2026.1776538. eCollection 2026.
ABSTRACT
Several studies on the use of platelet concentrates show different results. For example, while many studies demonstrate significant benefits of using PCs in tissue regeneration, others report modest or no results, creating uncertainty about the actual clinical usefulness of these PCs. This confusion also arises from the different protocols used to prepare platelet concentrates, which became clearer after the classification of PCs based on the presence of leukocytes and the organization of fibrin. Currently, we have numerous devices available to obtain PCs with specific characteristics typical of each method, such as APG, PRF, PRGF, CGF, etc. On one hand, this wide range of options offered by companies creates confusion; on the other hand, it allows us to have systems that provide a uniform product for all operators by standardizing centrifugal force, the type of vial used, its inclination, and rotation time. The aim of this mini review is to provide an overview of the applications of Autologous Platelet Concentrates (APCs) and their clinical application.
PMID:41816106 | PMC:PMC12971706 | DOI:10.3389/fcell.2026.1776538