Piezoelectric-Driven Cu2+/Cu+ Conversion Strategy for Amplifying Cuproptosis and Oxidative Stress

Scritto il 23/10/2025

da Xujian Yang

To overcome the efficiency limitations of cuproptosis in oncology, we engineered a piezoelectric Cu-loaded Bi(4)Ti(3)O(12) nanosheet system for synergistic cuproptosis and ROS-mediated tumor therapy. The incorporation of Cu^(2+) not only enhanced the material's piezoelectric coefficient (d(33) = 22.3 pm·V^(-1)) but also facilitated valence-state modulation under ultrasound (US) stimulation. The resulting piezoelectric field significantly promoted charge separation, accelerating Cu^(2+)/Cu^(+)...

ACS Appl Mater Interfaces. 2025 Oct 22. doi: 10.1021/acsami.5c17223. Online ahead of print.

ABSTRACT

To overcome the efficiency limitations of cuproptosis in oncology, we engineered a piezoelectric Cu-loaded Bi₄Ti₃O₁₂ nanosheet system for synergistic cuproptosis and ROS-mediated tumor therapy. The incorporation of Cu²⁺ not only enhanced the material's piezoelectric coefficient (d₃₃ = 22.3 pm·V^-1) but also facilitated valence-state modulation under ultrasound (US) stimulation. The resulting piezoelectric field significantly promoted charge separation, accelerating Cu²⁺/Cu⁺ conversion and boosting reactive oxygen species (ROS) generation. This strategy synergistically induces tumor cell death through a dual tumoricidal pathway: on one hand, the accumulation of Cu⁺ under US stimulation further amplifies cuproptosis, and on the other hand, the continuous accumulation of ROS triggers excessive oxidative stress. In a murine breast cancer model, this synergistic approach achieved a 90.6% tumor inhibition rate. This study pioneeringly combines piezoelectric material properties and copper valence transformation, providing insights for breast cancer treatment.

PMID:41126491 | DOI:10.1021/acsami.5c17223